BME 381 Implantable Materials & Biological Response

 Course Description: 

BME 381 combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystem; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.

 Prerequisites: BIOL K101, CHEM C106

 Instructor: TBD

 Instructional Goals: To help students know implantable biomaterials and better understand interactions between the implants and biosystem

 General Lecture Topics:

Overview of basic materials science

Overview of implantable materials & their biological responses

Interactions between implantable materials and tissue

Humoral and cellular immunology

Inflammation and implantable materials

In vitro and in vivo biocompatibility and their tests

Fundamental tools for characterization of interactions between implants and tissue

Blood-cardiovascular implant (stent) interaction

Tooth-dental implant interaction

Bone-orthopedic implant interaction

Eye tissue-ophthalmic implant interaction

Tissue-drug release device interaction

Skin tissue-wound healing material interaction 

Required Textbooks: Tissue-Biomaterial Interactions, K.C. Dee, D.A. Puleo, R. Bizios. ISBN 0-471-25394-4.  Printed handouts related to special topics will be provided. 

Additional Reading Materials:

Biomaterials Science, An Introduction to Materials in Medicine, B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons. ISBN 0-12-582461-0. 

Outcomes:

After completion of the course students are expected to know basic implantable biomaterials, understand interactions between implantable biomaterials and tissues, know how to select and use basic in vitro and vivo biocompatibility tests to evaluate the tissue response to the implantable biomaterials, and know how to characterize the interfaces between the implant and biosystem.