BME 383 Problems in Implantable Materials & Biological Response

Course Description:  

BME 383 is a corequisite course to BME 381, supplementing the basic science of BME 381 with quantitative, analytical examples and problems related to fundamental engineering principles in implantable materials.  Topics include:  microstructure, phase transformation, processing and design issues related to major engineering materials used for implantation purposes. 

Prerequisites:  CHEM C106 and BME 241

Corequisite:  BME 381

Instructional Goals:  To develop the engineering principles behind the microstructure-property-processing relationship in implantable materials.

General Lecture Topics:

Overview of implantable materials & their biological responses

Analysis of interactions between implantable materials and tissue

Applying in vitro and in vivo compatibility tests

Applying fundamental engineering tools to characterize interactions between implants and tissue

Quantitative analysis of:

- Blood-cardiovascular implant (stent) interaction

- Tooth-dental implant interaction

- Bone-orthopedic implant interaction

- Eye tissue-ophthalmic implant interaction

- Tissue-drug release device interaction

- Skin tissue-wound healing material interaction

Required Textbooks:  Tissue-Biomaterial Interactions, K.C. Dee, D.A. Puleo, R. Bizios. ISBN 0-471-25394-4.  Printed handouts related to special topics will be provided.

Additional Reading Materials:

Biomaterials Science, An Introduction to Materials in Medicine, B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons.  ISBN 0-12-582461-0.

Outcomes:

After completion of the course students are expected to better understand interactions between implantable biomaterials and tissues, know how to select and use basic in vitro and in vivo compatibility tests to evaluate the tissue response, and know how to characterize the interfaces between the implant and biosystem.