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Degrees:
PhD in Biomedical Engineering
BME News: |
Ghassan S. Kassab, Ph.D.
Thomas J. Linnemeier Guidant Chair
Professor of Biomedical Engineering
Professor of Surgery, Cellular and Integrative Physiology
Biomedical Engineering Department
Contact:
635 Barnhill Drive
MS 2069
Indianapolis, IN 46202
(317) 274-8337
gkassab@iupui.edu
Education:
Ph.D. Bioengineering, UCSD; Thesis Advisor: Y.C. Fung (1990)
M.S. Engineering Sciences, UCSD (1987)
B.S. Chemical Engineering, UCSD (1986)
Postdoctoral training:
Professor, Department of Biomedical Engineering, University of California, Irvine (2004-2006)
Professor, Department of Medicine (Cardiology), University of California, Irvine (2004-2006)
Professor, Department of Mechanical and Aeronautical Engineering, University of California, Irvine (2004-2006)
Associate Professor, Department of Biomedical Engineering, University of California, Irvine (2001-2004)
Associate Researcher, Department of Bioengineering, University of California, San Diego (1997-2001)
Danish Research Academy's Guest Professor, Denmark (1996)
Assistant Researcher, Department of Bioengineering, University of California, San Diego (1992-1997)
AHA Postdoctoral Fellow, AMES (Bioengineering), University of California, San Diego (1990-1992)
Research area : vascular networks, coronary circulation in health and disease, tissue remodeling, tissue engineering, simulation of complex biological systems
Our current research interests encompass the biomechanics of the cardiovascular system in health and diseases such as hypertension, flow-overload and heart failure. We are interested in the structure-function relationship in the cardiovascular system and in particular the coronary circulation under physiological and patho-physiological states. Our approach includes both experimental and computational studies. We utilize the experimental reductionist approach to dissect the coronary vascular system into its molecular, cellular and tissue components (e.g., nitric oxide, endothelium, micro-structural components of the vessel wall, blood vessel wall, etc. as shown in figure). The computational integrative approach is then used to synthesize the entire coronary vascular circuit to understand the whole organ.
Laboratory research and experimental methodologies
Our experimental procedures are performed on the swine, rat, and mouse models.
Selected Publications:
Lu, X and G.S. Kassab. Nitric Oxide is Significantly Reduced in ex vivo porcine arteries during Reverse Flow because of Increased Superoxide Production. J. Physiology 561(2): 575-582, 2004.
Mittal, N., Y. Zhou, C. Linares, S. Ung, B. Kaimovitz, S. Molloi and G.S. Kassab. Analysis of Blood Flow in the Entire Coronary Arterial Tree. Am. J. Physiol. Heart Circ. Physiol. 289: H439-446, 2005.
Kassab, G.S. A functional hierarchy of coronary circulation: Direct evidence of a structure-function relation. Am. J. Physiol. 289: H2559 - H2565, 2005.
Kassab, G.S. Design Laws of Vascular Trees: Of Form and Function. Am. J. Physiol., 290: H894 - H903, 2006.
Choy, J.S. and G.S. Kassab. A novel strategy for increasing wall thickness of coronary venules prior to retroperfusion. Am J Physiol Heart Circ Physiol . 291(2): H972-8, 2006.
Huo Y. and G.S. Kassab. Pulsatile blood flow in the entire coronary arterial tree: Theory and Experiment. Am. J. Physiol., 291(3): H1074-87, 2006.
Wang, C, M. Garcia, X. Lu, Y. Lanir and G.S. Kassab. A Three-Dimensional Model of Mechanical Properties of Coronary Artery: A Two Layer Model. Am. J. Physiol, 291(3): H1200-9, 2006.
Kassab, G.S. , M. Kostelec, J. Covell, A. Sadeghi, J.I.E. Hoffman and G. Buckberg. Myocardial Protection in the Failing Heart under Simulated Left Ventricular Restoration: III. Effect of Pulsatile Cardioplegic Perfusion. J. Thorac. Cardiovasc. Surg 132(4): 884-90, 2006.
Kassab, G.S. Y.C. “Bert” Fung: The Father of Modern Biomechanics. Mechanics and Chemistry of Biosystems 1(1): 5-22, 2004.
Kassab, G.S. and J.A. Navia. Biomechanical Considerations in the Design of Graft: The Homeostasis Hypothesis. Annu Rev Biomed Eng . 8: 499-535, 2006.