Biomedical Engineering: Purdue School of Engineering and Technology, IUPUI

Department of Biomedical Engineering

Ping Zhang, M.D.
Assistant Research Professor
Department of Biomedical Engineering

Contact:
723 West Michigan Street, SL-171
Indianapolis, IN 46202
(317) 274-5957 (office); (317) 278-2455 (fax)
pizhang@iupui.edu

Education:
M.S. Medical Sciences (July 1992)
M.D. Clinical Medicine (July 1983)

Postdoctoral training:
Biomedical Engineering, Indiana University - Purdue University Indianapolis; and Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN (2005-2006)
Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN (2002-2005)

Research area: Bone adaptation using animal models such as mice, rats, and rabbits. Four particular areas include:

Anatomical, physiological and mechanical characterization of bones and joints under mechanical loading.
Identification of cellular and molecular mechanisms involved in mechanotransduction of bone and joint cells.
Formulation and evaluation of genome-wide gene regulation involved in osteogenesis and chondrogenesis
Development of a loading strategy to prevent bone loss in patients with osteoporosis.

Experimental methodologies

Development of surgical procedures and models for studying bone adaptation and bone lengthening.
Fabrication and application of unique loading devices.
Application of cutting-edge imaging modalities.
Building mathematical models for gene regulation.

Selected Publications:

Zhang, P., Turner, C.H., Yokota, H. Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles. Bone 2009; 44: 989-998.

Zhang, P., Hamamura, K., Yokota, H., Malacinski, GM. Potential applications of pulsating joint loading in sports medicine. Exerc Sport Sci Rev 2009; 37:52-56.

Zhang, P., Hamamura, K., Yokota, H. Lengthening of mouse hindlimbs with knee loading. J Bone Miner Metab (in press).

Zhang, P., Liang, Y., Kim, H., Yokota, H. Evaluation of a pig osteonecrosis model in the femoral head. BMC Musculoskel Dis (in press).

Chen, A., Hamamura, K., Zhang, P., Chen, Y., Yokota, H. Systems Analysis of bone remodeling as a homeostatic regulator. IET Systems Biology (in press).

Zhang, P., Malacinski, G.M, Yokota, H. Joint Loading Modality: Its Application to Bone Formation and Fracture Healing. Brit J Sport Med 2008; 42:556-560.

Zhang, P., Yokota, H. Knee loading promotes longitudinal bone growth in both young and adult mice. Bone 2008, 43:S42.

Wang, Y., Thomas, D., Zhang, P., Yokota, H., Yang, L. Whole field strain measurement on complex surfaces by digital speckle pattern interometry. Materials Evaluation 2008; 507-512.

Zhang, P., Hamamura, K., Yokota, H. A brief review of bone adaptation to unloading. Geno Prot Bioinfo 2008; 6:4-7.

Hamamura, K., Zhang, P., Yokota, H. IGF2-Driven PI3 Kinase and TGFbeta Signaling Pathways in Chondrogenesis. Cell Biol Int 2008; 32: 1238-1246.

Zhang, P., Sun, Q., Turner, C.H., Yokota, H. Knee loading accelerates bone healing in mice. J Bone Miner Res 2007; 22: 1979-1987.

Zhang, P., Su, M., Liu, Y., Hus, A., Yokota, H. Knee loading dynamically alters intramedullary pressure in mouse femora. Bone 2007; 40: 538-543.

Zhang, P., Yokota, H. Effects of surgical holes in mouse tibiae on bone formation induced by knee loading. Bone 2007; 40:1320-1328.

Zhang. P., Tanaka, S., Sun, Q., Turner, C.H., Yokota, H. Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading. J Bone Miner Metab 2007; 25: 383-391.

Yang, L., Zhang, P., Liu, S., Samala, P., Yokota, H. Measurement of strain distributions in mouse femora with 3D-Digital Speckle Pattern Interferometry. Opt Laser Eng 2007; 45: 843-851.

Zhang, P., Tanaka, S., Jiang, H., Su, M., Yokota, H. Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol 2006; 100: 1452-1459.

Zhang, P., Su, M., Tanaka, S., Yokota, H. Knee loading causes diaphyseal cortical bone formation in murine femurs. BMC Musculoskel Dis 2006; 73: 1-12.

Su, M., Jiang, H., Zhang, P., Liu, Y., Wang, E., Hus, A., Yokota, H. Load-driven molecular transport in mouse femur with knee-loading modality. Ann Biomed Eng 2006; 34: 1600-1606.

Su, M., Zhang, P., Yokota, H., Malacinski, G.M. Development of a knee-loading joint supporter for potential use in preventing bone loss during spaceflight/aging. Biol Sci Space 2005; 19: 245-249.

Yossef, E.A., Zhang, P., Rogers, P., Tremble, P., Rokovich, J., Johnstone, B.H, March, K.L, Hou, D. Enhancing myocardial plasmid expression by retrograde coronary venous delivery. Catheter Cardiovasc Interv 2005; 65: 528-534.

Hou, D., Youssef, E.A., Brinton, T.J., Zhang, P., Rogers, P., Price, E.T, Yeung, A.C., Johnstone, B.H., Yock, P.G., March, K.L. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation 2005; 112: I150-I156.

Hou, D., Narciso, H., Kamdar, K., Zhang, P., Barclay, B., March, K.L. Stent-based nitric oxide delivery reducing neointimal proliferation in a porcine carotid overstretch injury model. Cardiovasc Intervent Radiol 2005; 28: 60-65.

Zhang, P., March, K.L., Hou, D. Physical training and cardioprotection. Chin J Sports Medicine. 2003; 22: 378-382.

Hou, D., Zhang, P., Marsh, A.E., March, K.L. Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstreth. J Chin Med Assoc 2003; 66: 637-642.