Ping Zhang , M.D.
Assistant Research Professor,
Biomedical Engineering Department

Contact:
Fesler Hall 115, 1120 South Drive
Indianapolis, IN 46202
317.274.5957
pizhang@iupui.edu

Education:
M.S. Medical Sciences (July 1992)
M.D. Clinical Medicine (July 1983)

Postdoctoral training:
Biomedical Engineering, Indiana University - Purdue University Indianapolis; and Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN (2005-2006)
Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN (2002-2005)

Research area : Bone adaptation using animal models such as mice, rats, and rabbits. Four particular areas include:

•  Anatomical, physiological and mechanical characterization of bones and joints under mechanical loading.
•  Identification of cellular and molecular mechanisms involved in mechanotransduction of bone and joint cells.
•  Formulation and evaluation of genome-wide gene regulation involved in osteogenesis and chondrogenesis.
•  Development of a loading strategy to prevent bone loss in patients with osteoporosis.

Experimental methodologies

•  Development of surgical procedures and models for studying bone adaptation.
•  Fabrication and application of unique loading devices.
•  Application of cutting-edge imaging modalities.
•  Building mathematical models for gene regulation.

Selected Publications:

Zhang. P ., Sun, Q., Turner, C.H., Yokota, H. Knee loading accelerates bone healing in mice. J Bone Miner Res 2007; 22: 1979-1987.

Zhang, P ., Su, M., Liu, Y., Hus, A., Yokota, H. Knee loading dynamically alters intramedullary pressure in mouse femora. Bone 2007; 40: 538-543.

Zhang, P ., Yokota, H. Effects of surgical holes in mouse tibiae on bone formation induced by knee loading. Bone 2007; 40:1320-1328.

Zhang. P ., Tanaka, S., Sun, Q., Turner, C.H., Yokota, H. Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading. J Bone Miner Metab 2007; 25: 383-391.

Zhang, P ., Malacinski, G.M., Yokota, H. Joint Loading Modality: Its Application to Bone Formation and Fracture Healing. Brit J Sport Med 2007 (in press).

Zhang, P ., Hamamura, K., Yokota, H. Bone adaptation to unloading. Genomics Proteomics Bioinformatics 2007 (in press).

Yang, L., Zhang, P ., Liu, S., Samala, P., Yokota, H. Measurement of strain distributions in mouse femora with 3D-Digital Speckle Pattern Interferometry. Opt Laser Eng 2007; 45: 843-851.

Zhang, P ., Tanaka, S., Jiang, H., Su, M., Yokota, H. Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol 2006; 100: 1452-1459.

Zhang, P ., Su, M., Tanaka, S., Yokota, H. Knee loading causes diaphyseal cortical bone formation in murine femurs. BMC Musculoskel Dis 2006; 73: 1-12.

Su, M., Jiang, H., Zhang, P ., Liu, Y., Wang, E., Hus, A., Yokota, H. Load-driven molecular transport in mouse femur with knee-loading modality. Ann Biomed Eng 2006; 34: 1600-1606.

Su, M., Zhang, P ., Yokota, H., Malacinski, G.M. Development of a knee-loading joint supporter for potential use in preventing bone loss during spaceflight/aging. Biol Sci Space 2005; 19: 245-249.

Yossef, E.A., Zhang, P ., Rogers, P., Tremble, P., Rokovich, J., Johnstone, B.H, March, K.L, Hou, D. Enhancing myocardial plasmid expression by retrograde coronary venous delivery. Catheter Cardiovasc Interv 2005; 65: 528-534.

Hou, D., Youssef, E.A., Brinton, T.J., Zhang, P ., Rogers , P., Price, E.T, Yeung, A.C., Johnstone, B.H., Yock, P.G., March, K.L. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation 2005; 112: I150-I156.

Hou, D., Narciso, H., Kamdar, K., Zhang, P ., Barclay, B., March, K.L. Stent-based nitric oxide delivery reducing neointimal proliferation in a porcine carotid overstretch injury model. Cardiovasc Intervent Radiol 2005; 28: 60-65.

Zhang, P ., March, K.L., Hou, D. Physical training and cardioprotection. Chin J Sports Medicine . 2003; 22: 378-382.

Hou, D., Zhang, P ., Marsh, A.E., March, K.L. Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstreth. J Chin Med Assoc 2003; 66: 637-642.