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IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Implantable Systems

BME 52700 / 3 Cr.

Engineering constraints surrounding the selection of a power source for an implantable system and in particular how the control of the target organ system impacts power plant design. The organ specific design of cochlear neuroprosthetics, functional neuromuscular stimulation systems and cardiac pacemakers are presented in detail as but three examples of technically mature implantable systems that have had broad clinical impact. For each, there is a brief introduction to the related anatomy, physiology and neurophysiology of the target organ system so that students may gain perspective on the functional limits of the artificial control of these organ systems. Several implantable systems presently in the early stages of bioengineering design or in the early stages of clinical trials are presented as state-of-the-art examples. Particular attention is given to practical bioengineering issues related to the ever expanding use of implantable biomedical sensors in order to provide real-time control of the implant and improved response to challenges to the homeostasis of organ system function. Issues related to ethical and regulatory considerations related to implantable system design including animal testing, human clinical trials and FDA premarket approval are also introduced.