BME 411

Department of Biomedical Engineering

BME 411 Quantitive Physiology

Course Description: BME 411 is an introductory course in physiological systems and an introductory course in classical feedback control theory for biomedical engineers. It aims to apply systems theory and classical feedforward and feedback control in the context of physiological systems. Approximately a third of the course will be devoted to physiological systems, a third to classical control theory and a third to the application of classical control and systems theory to physiological systems.

Prerequisites: BME 331

Instructor: Ken Yoshida, PhD.

Textbooks: Control textbook: Franklin, Powell and Emami-Naeini, Feedback Control of Dynamic Systems, 5th ed., Pearson Prentice Hall Press, ISBN 0121488300
Physiology textbook: Berne, Levy, Koeppen & Stanton, Physiology, 5th ed, Elsevier Mosby, ISBN 03230339903 or Guyton & Hall, Textbook of Medical Physiology, 11th ed., Elsevier Saunders, ISBN 9870721602400

Outline of Topics: (roughly by lectures, order may vary)

Review of Linear Systems (C)
Resting Membrane Potentials (P)
Poles and Zeros (C)
Action Potentials (P)
Time Domain Specifications (C)
Peripheral Nervous System (P)
Skeletal Muscles (P)
Dynamic Response, Stability (C)
Synaptic Transmission, Neuromuscular Junction (P)
Feedback Controllers (C)
Muscle Afferents (P)
Frequency Domain Analysis, Bode Plots, Root Locus (C)
Smoot and Cardiac Muscles (P)
System Identification (C)
Somatosensory System (P)
Special Systems (P)
Physiological Control Systems

Instructional Goals:

After completion of this course the successful student should be able to:

Describe major physiological features of the peripheral nervous system, skeletal muscle, and other physiological systems. [l]
Analyze and model dynamic physiological systems from the literature using linear systems techniques. [a,b,c,l,m]
Design feedback controllers for linear systems. [a,e]
Analyze the stability of a system that relies on feedback. [a,e]
Analyze frequency response and construct Bode plots. [a,k]
Work in teams to understand and implement a model of a physiological system. [d]

Grading

Homework 5%

Exam 1 15%

Exam 2 15%

Group Project 25%

Presentations 10%

Final Exam 30%