Dong Xie, Ph.D.
Associate Professor, Department of Biomedical Engineering
Associate Professor, Department of Surgery, School of Medicine
Contact:
723 W. Michigan St. SL 220E
Indianapolis, IN 46202
(317)-274-9748
dxie@iupui.edu
NIH Biosketch (*.pdf)
Education:
Ph.D. Polymeric Biomaterials/Oral Biology, Ohio State University (1998)
Postdoctoral training:
Department of Chemistry, University of Alabama at Birmingham (1998-1999)
Research area : Advanced biomaterials for dental restoratives and orthopedics; Biodegradable polymers for tissue engineering; Functional polymers for regenerative medicine
Dr. Xie works primarily in the area of advanced polymeric biomaterials. One major goal in this emerging field is to develop novel polymers and their composites for dental and orthopedic applications, which include hard tissue and soft tissue restorations. The second main goal in this field is to develop novel biodegradable polymer and composite systems for tissue engineering, which includes design and formulation of deliverable, in situ polymerizable and resorbable polymers as tissue scaffolds for soft and hard tissue regenerations.
More recently, Dr. Xie has begun to work on regenerative medicine, specifically in the area of immune protection of cell or organ transplantations. He initiated collaboration with Dr. Pescovitz, Director of Organ Transplant at Indiana University Medical Center on pancreatic islet transplantations. The goal of this research is to engineer tissue compatible polymers to pancreatic islets to completely diminish all the detrimental immune and complement-mediated reactions that may occur during islet allo- or xenotransplantations and to prevent loss of islet mass, which will dramatically impact millions of patients in need of pancreatic islet transplantation.
Dr. Xie joined the faculty of Department of Biomedical Engineering at IUPUI in August, 2004. Prior to that, he was a faculty member in Department of Biomedical Engineering at University of Alabama at Birmingham for approximately four years after he completed his postdoctoral training with Professor Jimmy Mays in Department of Chemistry. He received his Ph. D. at Ohio State University in 1998. He had over 38 peer-reviewed publications and over 30 presentations in national and international conferences. He was co-principal investigator for NSF funded three campus project (EPS-0083128) and principal investigator for currently NIBIB/NIH funded project (R01 EB003162).
Laboratory research and experimental methodologies
1. Synthesis and characterization of biocompatible oligomers and polymers
2. Formulation and evaluation of synthesized polymers and composites
- Strength testing, toughness, hardness, bonding, SEM evaluation
3. Biocompatibility test
- In vitro cell culture studies and in vivo studies using animal models
Xie, D., Smyth, C.A., Eckstein, C., Bilbao, G., Mays , J., Eckhoff, D.E., Contreras, J.L. Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation, Biomaterials , 2005; 26(4):403-412 .
Xie, D., Chung, I-D., Wang, G., Feng, D., Mays, J., Synthesis, formulation and evaluation of novel zinc-calcium phosphate-based adhesive resin composite cement, Eur. Polym. J ., 2004; 40(8):1723-1731.
Xie, D. , Chung, I-D., Wu, W., Lemons, J., Puckett, A., and Mays , J. An amino acid modified and non-HEMA containing glass-ionomer cement, Biomaterials , 2004; 25(10):1825-1830 .
Xie, D. , Chung, I-D., Wu, W., and Mays , J., Synthesis and evaluation of HEMA-free glass-ionomer cements for dental applications, Dent. Mater., 2004; 20:470-478.
Xie, D. , Wu, W., Puckett, A., Farmer, B., and Mays , J., Novel Resin Modified Glass Ionomer Cements with Improved Flexural Strength and Ease of Handling, Eur. Polym. J ., 2004; 40(2):343-351.
Xie, D. , Feng, F., Chung, I-D., and Eberhardt, A.W., A hybrid zinc-calcium-silicate polyalkenoate bone cement , Biomaterials , 2003; 24(16):2749-2757.
Chung, I-D., Xie, D. , Puckett, A., and Mays , J., Syntheses and evaluation of novel biodegradable amino acid based anhydride polymer resins and composites, Eur. Polym. J ., 2003; 39:497-503.
Wu, W., Xie. D. , Puckett, A., and Mays , J., Synthesis and formulation of vinyl-containing polyacids for improved light-cured glass-ionomer cements, Eur. Polym. J ., 2003; 39:663-670.
Wu, W., Xie. D. , Puckett, A.,and Mays , J., Synthesis and characterization of self-cured amino acid modified glass-ionomers, Eur. Polym. J . , 2003; 39:959-968.
Chung, I-D., Xie, D. , Puckett, A., and Mays , J., Syntheses and Evaluation of Biodegradable Multifunctional Polymer Networks, Eur. Polym. J ., 2003; 39: 1817-1822.
