Tien-Min Gabriel Chu, Ph.D.
Assistant Professor,
Department of Biomedical Engineering
Adjunct Assistant Professor,
Department of Orthopaedic Surgery
Adjunct Assistant Professor,
Department of Restorative Dentistry
Contact:
1120 South Drive
Room FH RM 115L
Indianapolis, IN 46202
(317)-278-8716
Fax: (317) 278-9568
tgchu@iupui.edu
NIH Biosketch (*.pdf)
Education:
Ph.D. Joint degree of Biomaterials and Materials Sciences and Engineering, University of Michigan , Ann Arbor , MI . 1999
D.D.S. School of Dentistry , Kaohsiung Medical College , Taiwan , 1989
Postdoctoral training:
Department of Materials Science and Engineering, University of Michigan , Ann Arbor , MI. (1999-2000)
Department of Biomedical Engineering, University of Michigan , Ann Arbor , MI. (2000-2001)
Research area : Bone tissue engineering
Each year, approximately 6 million fractures occur in the United States which requires a total of 9 million physician visits and causes a loss of more than 36 million work days (American Academy of Orthopaedic Surgeon). One particular challenging condition that fracture can leave with the patient is segmental defects. Large segmental defects are often hard to manage and require multi-phase surgery to restore sufficient function and union. Current treatment options include autografts, allografts, and distraction osteogenesis. Though these treatments have brought forth clinical successes, they are still with considerable limitations. To overcome the limitations in these treatment options, researchers are exploring for new treatment methodologies. In our laboratory, we are investigating the use of rapid prototyping technique for manufacturing biodegradable, load-bearing bone tissue engineering scaffolds, and the in vivo evaluation of such scaffolds.
1. High Strength Smart Scaffolds
- CAD design and 3D printing
- In vitro degradation study on pH and strength
2. Mesoscopic topological effects on osteoblasts
- Scanning electron microscopy
- Osteoblast proliferation assay
- Osteoblast total protein assay
3. Tissue Engineering of Segmental Defects
- In vivo implantation in rat femurs
- x-ray, pQCT, DXA, and mechanical testing
Selected Patents and Publications:
1. US Patent 6,117,612 “StereoLithography Resin for Rapid Prototyping of Ceramics and Metals” M.L. Griffith, M.L., Halloran, J.W., and Chu , T.M.
2. “Design methodology for tissue engineering scaffolds and biomaterial implants” Hollister, Scott J.; Chu, Gabriel Tien-Min; Taboas, Juan M (US patent pending)
3. “Controlled local/global and micro/macro-porous 3D plastic, polymer and ceramic/cement composite scaffold fabrication and applications thereof” Taboas, Juan M; Maddox, Rachel D.; Krebsbach, Paul H . ; Hollister, Scott J.; Chu, Tien-Min Gabriel (US patent pending)
4. T-M. G. Chu "Solid Freeform Fabrication of Tissue Engineering Scaffolds" in Scaffolding in Tissue Engineering, Eds. X. Ma and J. Eliseeff, Marcel Dekker, Inc., 2004 (in press)
5. Hollister, S.J., Taboas, J.M., Schek, R.M., Lin, C.Y., and Chu , T.M. (2004) "Design and Fabrication of Bone Tissue Engineering Scaffolds" in Bone Tissue Engineering, Eds, Hollinger et al. CRC Press LLC. (in press)
6. T-M. G. Chu, S.J. Hollister, J.W. Halloran, S.E. Feinberg, D.G. Orton, “Manufacturing and Characterization of 3D Hydroxyapatite Bone Tissue Engineering Scaffolds” in Annuals of New York Academy of Science Vol. 961 - Reparative Medicine: Growing Tissues and Organs, Eds. J.D. Sipe, C.A. Kelley, and L.A. McNichol. New York Academy of Science , NY . p.114-117, 2002
7. T-M. G. Chu , D.G. Orton, J.W. Halloran, S.J. Hollister, S.E. Feinberg, “Mechanical and in vivo performance of hydroxyapatite implants containing controlled internal architecture” Biomaterials 23 (2002) p.1283-1293
8. T-M. G. Chu, J.W. Halloran, S.J. Hollister, S.E. Feinberg, “Hydroxyapatite implants with controlled internal architecture” Journal of Materials Science: Materials in Medicine 12 (2001) p.471-478
9. S.E. Feinberg, S.J. Hollister, J.W. Halloran, T.M.G. Chu, and P.H. Krebsbach, “Image-Based Biomimetic approach to reconstruction of the temporomandibular joint” Cells Tissues Organs 163 (2001) p.309-321
10. Hollister, S.J., Zysset, P.K., Guldberg, R.E., Chu , T.M. and Halloran, J.W. "Engineering microstructures to evaluate and replace trabecular bone." Adv Exp Med Biol 496 (2001) p.199-211.
11. T-M. G. Chu, and J.W. Halloran, “High-Temperature Flow Behavior of Ceramic Suspensions” Journal of the American Ceramic Society 83 (2000) p.2189-2195
12. T-M. G. Chu and J.W. Halloran, “Curing of highly-loaded ceramic suspensions in acrylates” Journal of the American Ceramic Society 83 (2000) p.2375-2380
13. S.J. Hollister, T.M. Chu, J.W. Halloran, and S.E. Feinberg, “Design and Manufacture of Bone Replacement Scaffolds”, in Bone Mechanics , Stephen Cowin, Ed., CRC Press, p.36-1 - 36-14, 2001
14. S.J. Hollister, T.M. Chu, R.A. Levy, J.W. Halloran, and S.E. Feinberg, “An Image-Based Approach for Designing and Manufacturing Craniofacial Scaffolds” International Journal of Oral and Maxillofacial Surgery 29 (2000) p.67-71
15. S.E. Feinberg, S.J. Hollister, J.W. Halloran, T.M. Chu, and P.H. Krebsbach, “Role of biomimetics in reconstruction of the temporomandibular joint ” in Oral and Maxillofacial Surgery Clinics of North America ., Vol 12, No.1, Feb. 2000 issue on Total Temporomandibular Joint Reconstruction, William C. Donlon, Ed., W.B. Saundrs Company, p.149-160, 2000
16. S.E. Feinberg, S.J. Hollister, J.W. Halloran, T.M. Chu, and P.H. Krebsbach, “A tissue engineering approach to site-specific reconstruction of skeletal structures of the maxillofacial region: Part I” Shanghai Journal of Stomatology 9 (2000) p.36-40
17. S.E. Feinberg, S.J. Hollister, J.W. Halloran, T.M. Chu, and P.H. Krebsbach, “A tissue engineering approach to site-specific reconstruction of skeletal structures of the maxillofacial region: Part II” Shanghai Journal of Stomatology 9 (2000) p.88-93
18. S.J. Hollister, T.M. Chu, R.E. Guldberg, P.K. Zysset, R.A. Levy, J.W. Halloran, S.E. Feinberg, “Image based design and manufacture of scaffolds for bone reconstruction”, in IUTAM Synthesis in Biosolid Mechanics, Pedersen, P. and Bendsoe, M. Eds., Kluwer Press, p 163-174, 1999
19. R. Levy, T.M. Chu, J.W. Halloran, S.E. Feinberg, and S. Hollister, “CT-Generated Porous Hydroxyapatite Orbital Floor Prosthesis as a Prototype Bioimplant ” American Journal of Neuroradiology AJNR 18 (1997) p. 1522-1525
20. W. Wagner and T.M. Chu, “Biaxial flexural strength and indentation fracture toughness of three new dental core ceramics” Journal of Prosthetic Dentistry 76 (1996) p.140-144
